Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance.

نویسندگان

  • Mathieu Hernould
  • Séverine Gagné
  • Michel Fournier
  • Claudine Quentin
  • Corinne Arpin
چکیده

Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylalanine-arginine-beta-naphthylamide (PAbetaN) revealed an additional system(s) contributing to intrinsic resistance. This is the first analysis of the role of multidrug efflux systems in Aeromonas spp.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 4  شماره 

صفحات  -

تاریخ انتشار 2008